Orlovsky M. The state of cholecystokinin-synthesizing hypothalamic system and the role of cholecystokinin-8 in regulation of endocrine pancreas function in the norm and under experimental diabetes mellitus

The dissertation is devoted to studying the state of hypothalamic chole-cystokinin-synthesizing system and effects of synthetic cholecystokinin receptors agonist and antagonist administrations on endocrine pancreas function in the norm and during experimental diabetes mellitus. It is shown, that the highest cholecystokinin-8 synthesis level is observed in paraventricular and dorsomedial hypothalamic nuclei, but the most intensive chol-cystokininergic innervation is propertied to ventromedial nucleus. Diabetes mellitus is associated with development of hypothalamic cholecystokininergic system func-tional insufficiency, which was confirmed with the absence of effect in experiments with cholecystokinin antagonist multiple administrations. Multiple intraperitoneal, intracerebroventricular administrations and conjunctive instillations of synthetic cholecystokinine-8 improves endocrine pancreas function and decreases gravity of pathological process leading to decreasing of hyporphagy, glycaemia, beta-cells destruction and alpha-cells proliferation rates. High efficacy and noninvasiveness of multiple cholecystokinin conjunctive instillations method opens new perspectives for the therapy of diabetes mellitus.