Kukharskyy V. Place and role of tyrosine kinases Src and Syk families in intracellular signal transduction with participation of microtubules during neuronal differentiation

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0404U004080

Thesis Registration Form

0404U004080.pdf

Applicant for

Specialization

  • 03.00.11 - Цитологія, гістологія

27-10-2004

Specialized Academic Board

Д26.001.38

Essay

The object is mechanisms of neuronal differentiation. The aim to determine place and role of tyrosine kinases Src and Syk families in intracellular signal transduction with participation of microtubules during neuronal differentiation of embryonal carcinoma cell culture. The methods was used – cell culture technique, immunofluorescent and differential-contrast microscopy, protein concentration estimation, SDS-PAGE, immunobloting, ultracentrifugation, immunoprecipitation and kinase assay. The combined data suggest that Src and Syk family kinases play an important role in intracellular signal transduction during neuronal differentiation, interact with microtubules and signal to microtubule proteins.

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Files

Avtoref.doc

Dis.doc

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