Sopel O. The role of disturbances of free radical processes and endogenic intoxication in the pathogenesis of kidney damage amanita-phalloides poison and their correction

The dissertation is devoted to the studying of the free radical process, antioxidant system, nitric oxide system, endogenic intoxication markets in the blood and kidneys under the influence of amanita-phalloides poison and the correction of the detected biochemical changes by means of antioxidant thiotriazolinum and metallic complex cuprohistidinate. The experimental and theoretical substantiation of the influence of amanita-phallodes poison on the disturbance of excretory, ion regulating and acidexcreting functions of the kidney has been performed. It was first time that the pathogenic correlation between the level of lipid peroxidation products, oxidemodificative proteins level and antioxidant enzymes system activity, endogenic intoxication indeces and the development of dystrophy-necrotic damage of glomerulo-tubular system of the kidney under the influence of amanita-phalloides poison has been determined. The effectiveness of use of thyotriasolinum and сuprohistidinate for experimental amanita-phalloides poisoning treatment was found.