Grechishkina T. 3. Сharacteristics of the structure of the rat's gastric mucosa on exposure of volatile components of epoxy resin ED-20 into the organism and preventive treatment by quercetin.

The thesis devoted to study of the morphological basis of changes secretory functions of the fundal and pyloric mucosa of the rats stomach and its protective properties in condition of inhalation entrance of toxic material, be-ing included in volatile fraction of the epoxy resin ED-20. In an experimental study is shown that structure and protective characteristic of the stomach mucosa depend on activity reaction of freeradical processes in organism. At arrival in animal organism, the materials influencing upon lipid peroxide level, essential role in maintenance of structural homeostasis of the gastric mucosa plays the population of the mast cells both fundal and pyloric re-gions of the stomach as well. Their effect may is medi-ated by local endocrine cells. The directivity and expres-sion of structural changes is proportional to the influ-ences level of flying component of epoxy resins, possessing cumulative characteristic. For the first time for estimation of structure-functional characteristic of thegastric mucosa in condition of chronic toxic administration and pretreatment of the antioxidants was used an information analysis as a method of system-structural analysis. By means of integral criterions - entropy and redundancy - was installed the particularities of the mor-phological structures biological systems as well as mast cell populations and fundal glands of the stomach, shown specificity of their reactions after exposure with xenobi-otics. It was revealed that fundal glands are differed by lower adaptation-compensatory possibilities. Herewith by means of information criterion installed that signifi-cant disorganization of the fundal glands structure at toxic influence occurs long before appearance morpho-logical changes. It was also shown that epoxy-resin-induced injury of gastric mucosa could be decreased by quercetin pretreatment.