Dulceva E. The chemical and toxicological investigation of Аtenolol

The methods of colour and precipitation reactions, TLC, HPLC, GLC and UV-spectroscopy, have been offered in this thesis for the identification of Atenolol. The UV-spectrophotometric, extraction-photometric HPLC and GLC -metod of quantitative determination of Atenolol have been worked out. The conditions on pH medium have been studied. The comparative study of generally accepted extractive methods in chemical and toxicological analysis of substances (Stas-Otto, Vasilyeva, Kramarenko) for Atenolol has been conducted. The effective and expressive particular extractive method for Atenolol by Chloroform -Isopentanol (9:1) has been offered. The methods for Atenolol isolation from biological liquids of human organism (blood and urine) have been offered. On the basis of the carried out investigations the scheme of Atenolol chemical and toxicological analysis in extracts from biological material has been offered