Blagoveshchenskiy E. Clinical diagnostic description of perinatal period in young pregnant women with iron deficiency anemia and its treatment.

Object of the study: IDA in young pregnant. Purpose of the study: To reduce the incidence of obstetric and perinatal complications in young pregnant with IDA based on determining the clinical data, the state of immune and hormonal state as well as morphological and histochemical features in the afterbirth tissue. Methods of the study: Clinical laboratory, instrumental, hormonal, immunological, histochemical, morphometric, statistical. Practical significance: Basing on the analysis of clinical laboratory studies it was established that it is necessary to distinguish a high-risk group of development of perinatal pathology, complications of gestation and delivery. A complex of diagnostic measures aimed to improvement of prognosis of the course of pregnancy, delivery and postnatal period in young women with IDA was worked out. In young primipara with IDA, a complex of measures including the use of iron-containing drugs, namely Feroceron in combination with antioxidant antihypoxic drug Glutargin was introduced. High clinical efficacy of the suggested treatment not having any side or adverse effects was established. The use of the suggested therapeutic complex in the clinical practice promoted reduction of the incidence of perinatal pathology and obstetric complications. Novelty of the obtained results: For the first time, the features of the clinical course of pregnancy, delivery, the state of the newborn in young primipara with IDA depending on the anemia degree were described. It was established that IDA in young pregnant caused complications of the pregnancy course in 94.4% and delivery pathology in 85.5% of cases. Main pathogenetic mechanisms of adaptation of teen-age girls to gestation process against a background of IDA were established. The role of separate links of the immune system and the hormones of FPC during adaptation of the organism of young pregnant with IDA was shown. The features of hemodynamic disorders, intensity of metabolic synthetic processes and morphology of the placenta tissue in youngpregnant with IDA and their dependence on anemia degree were revealed. Diagnostic and therapeutic measures in young pregnant with IDA were substantiated and improved. Introduction: The findings of the research were introduced into the work of obstetrics department of Kharkiv Regional Clinical Hospital, Maternity Hospital No. 1 (Kharkiv), City Maternity Hospital with Neonatology Department (Kharkiv), department of pregnancy pathology of Balakliya CDH (Kharkiv region). The findings of the research are used in the teaching process of obstetrics and gynecology de-partments of Kharkiv State Medical University, Kharkiv Medical Academy for Post-graduate Treatment, in the research work of Research Institute for Immunology and Microbiology named after I.I. Mechnikov (Kharkiv). Sphere of application: medicine, obstetrics and gynecology.