Dresvyannikov A. Pharmaco-biophysical properties of the single muscarinic cationic channels in guinea-pig ileal smooth muscles

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U001573

Thesis Registration Form

0405U001573.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

05-04-2005

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

It was established that carbachol evoked inward cationic current in guinea-pig ileum smooth muscle cells is comprised of three types of nonselective cationic channels with small, medium and large unitary conductance.. It was found that behaviour of carbachol whole-cell current is mainly determined by the properties of medium conductance channels. The kinetic scheme with four pairs of connected states have been identified.It was found that Ca and Mg caused blocking action. The medium channel gating could occur spontaneously .

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Files

Diser_DresvyannikovAV.doc

Dresvyannikov_A_Ref.pdf

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