Stanika R. Effect of hypoxia on intracellular exchange of Ca2+ in rat sensory neurons

The dissertation is devoted to research of hypoxia influence on free intracellular calcium concentration ([Ca2+]in) in rats sensory neurons. It is shown, that hypoxia causes authentic increase of [Ca2+]in at 1.7-2.4 time that is more expressed in cells of small diameter. It is revealed, that the main pathway of increase [Ca2+]in in sensory neurons are voltage-gated Са2+ channels. Mitochondria are important for spatial difference in the hypoxia-induced Ca2+ elevation due to their specific location in these neurons. The involving of reverse mode Na+/Ca2+-exchanger in the hypoxic effect is insignificant. The effect of hypoxia on neurons of diabetes rats is smaller in comparison with the control group of animals.