Radchenko O. Clinical-haemodinamical and metabolic effects of moxonidine in the patients with metabolic-X syndrome

Dissertation is devoted to a study of left ventricular (LV) diastolic functions, heart rate variability, renin-angiotensine system activity and evaluation of the effects of moxonidine as a monotherapy and in combined with betaxolol and indapamid in relation to the clinical-haemodinamical and metabolic parameters at metabolic X - syndrome patients.It was established that the metabolic X - syndrome patients develop the considerably reduсed heart rate variability as compared to the patients with essential arterial hypertension and to the healthy persons. It was also revealеd the decrease of the spectrum total power, high-frequency and low- frequency components, with deviated sympathetic-vagal balance towards dominated sympathetic link of vegetative nervous system. It was registered in eighty five of per cent of metabolic X - syndrome patients the LV diastolic function disorder, mainly 71% of hypertrophyc type. This disorder demonstrated the dependents between the diastolical dysfunctions degree and LV hypertrophy, increased arterial blood pressure and its variability, glycemia level, compensative functional possibilities of pancreas in the conditions of insulin-resistance. It was revealed the increased angiotensine converting enzyme (ACE) activity as the diastolic dysfunction grows. It was proved the prevalence of all medical schemes and significance of combined therapy. The provided therapy influenced positively on carbohydrate and some parameters of lipid metabolism, ACE activity. It was proved the positive effect of moxonidine monotherapy and combined with betaxolol on the aggregation properties on thrombocytes.