Burenok Y. The clinical neurophysiological study on the efficacy of the magnetic laser therapy in a complex pathogenetic management of the Parkinson's disease at its various stages

This dissertation is concerned with the issues of the use and efficacy of magnetic laser therapy in the PD patients exposed to different levels of the drug therapy. The author has substantiated the use of magnetic laser therapy as a non-medicinal method in complex pathogenetic treatment of the PD.The clinical neurophysiological study was carried out in the parkinsonian patients before and after the magnetic laser course treatment, with the use of the following methods: unified UPDRS scales, electroencephalography, endogenous evoked potentials (cognitive P300 and conditioned negative wave), and electromyography. Determined were also the motor and sensorimotor reactions and the catecholamines in the urine.On the basis of complex approach to analysis of the brain functional activity, the author performed a clinico-neurophysiological evaluation of the central mechanisms of motor activity regulation at the various stages of disease progression. The novelty of this work consists in the performance of a comparative study of the functional state of the brain afferent systems and the mechanisms of different efficacy of pathogenetic antiparkinsonian therapy in PD patients at the various disease levels, with the use of evoked potentials and sensorimotor reactions at various treatment stages and with the evaluation of their diagnostic significance. The possibility for the use of magnetic laser therapy at all disease stages has been shown as a method ensuring the high effectiveness of medicinal treatment. Efficiency of the course magnetic laser therapy in PD patients has been found especially high in the patients treated with levodopa and in the primary patients who did not prior take antiparkinsonian drugs.