Ivakhnenko O. Passing, features, treatment and prophylaxis of gastroduodenal pathology among school children which is associated with Helicobacter pylori.

The aim of this study was to increase the effectiveness of diagnosis and treatment of children with chronic gastroduodenal pathology associated with H. pylori based on early disease recognition, investigation of clinical course peculiarities, using of up-to-date diagnostic methods and optimal schemes of eradication therapy. The obtained data showed that timely determination of functional disturbances and chronic diseases of upper digestive tract (DUDT) in school age children could be facilitated by use of screening questionnaire, selection of high-risk group of patients and their additional investigation. In all cases of typical complaints that correspond to DUDT screening analysis for H. pylori antibodies in capillary blood is recommended. If there are obvious clinical signs of the disease or the latter has recurrent clinical course fibrogastroduodenoscopy with a fine biopsy of gastric mucosa and its morphological study must be performed. Triple therapy with de-nol, flemoxine-solutab, and clarithromycine is recommended for the primary treatment of children with H. pylori associated diseases. The effectiveness of this eradication therapy is of 86,7%. If there are data about previous eradication therapy in medical history of a child or its ineffectiveness, treatment with de-nol, flemoxine-solutab, clarithromycine, and nexium should be used. Its effectiveness is of 93,3%. In a case of H. pylori associated disease in a child additional investigation of family members is needed and if the diagnosis is proved eradication therapy is recommended in order to eliminate the "family source" of infection and reduce the risk of child's re-infection.