Nazarko T. Molecular mechanisms of peroxisome degradation in the alkane-utilizing yeast Yarrowia lipolytica

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U002388

Thesis Registration Form

0405U002388.pdf

Applicant for

Specialization

  • 03.00.11 - Цитологія, гістологія

10-06-2005

Specialized Academic Board

К 35.246.01

Essay

Peroxisome degradation in the alkane-utilizing yeast Y. lipolytica. To investigate the molecular mechanisms of peroxisome degradation in the alkane-utilizing yeast Y. lipolytica. Methods of research are of molecular genetics, gene-engineering, microbiology, biochemistry and fluorescent microscopy. It was proven that Y. lipolytica peroxisomes are degraded in the vacuoles by a macropexophagic mechanism. The Y. lipolytica mutants affected in peroxisome degradation and general autophagy were isolated and characterized for the first time. It was investigated that the peroxisomes of these mutants were not able to get inside the vacuoles due to the defect of the YlTRS85 gene. It was shown that the Y. lipolytica peroxisome degradation in contrast to micro- and macropexophagy of the P. pastoris did not depend on the UGT51 gene. Sphere of use is the biotechnology.

Read more

Files

aref.doc

dis.doc

Similar theses

0524U000086

Galina V. Shevchenko

Cytoskeleton in the process of plant adaptation to simulated microgravity and hypoxia

0524U000027

Halyna Y. Hachkova

Molecular basis of antidiabetic action of biologically active substances isolated from medicinal plants Galega officinalis L. and Smallanthus sonchifolius (Poepp. et Endl.) H. Robinson

0521U102103

Kuznietsova Halyna

Influence of growth factors receptors nonspecific inhibitors on the inflammation-fibrosis-carcinogenesis axis (on the example of digestive organs)

0421U103577

Ryzhko Iryna Mykolaivna

Connective tissue cell reactions and mechanisms of systemic regulation of regenerative processes in local thermal injury on the background of hyperglycemia.

0421U102409

Byelyayeva Alyaksandra Viktorivna

Cytogenetic and morphofunctional parameters of stem cells under using candesartan cilexetil and resveratrol