Demenko A. Peculiarities of etiology, pathogenesis and immune reactivity in chronic traumatic osteomyelitis.

Object of the study: Monocytes and neutrophils of the blood from healthy subjects and patients with chronic os-teomyelitis, immune and metabolic parameters in patients with chronic traumatic osteomyelitis, bacteria - etiological agents of osteomyelitis. Purpose of the study: To reveal the features of pathoge-netic mechanisms of forming chronic traumatic osteomye-litis based on the study of etiological spectrum of the disease agents as well as their influence on the immune and meta-bolic parameters of the patients. Methods of the study: Immunological, bacteriological, ex-perimental, biochemical. Practical significance of the obtained findings: The ap-proaches to explanation of pathogenesis of CTO caused by facultative ans strict anaerobic conventionally pathogenic bacteria were determined based on the study of immune-inflammatory potential of bacterial peptidoglycans and lipo-polysaccharides, which allows to recommend the use of various schemes of treatment with immunomodualtors de-pending on the process severity. Novelty: For the first time, the etiological significance of the bacteria which had not been described earlier as etiological agents of the diseases before was established and proven. The presence of anti-complement, anti-lysosome, anti-immunoglobulin activity was established. For the first time it was noticed that bacteria caused species-specific inhibition of phagocyte activity of neutrophils and monocytes of the peripheral blood. It was established that inhibition of IL-1?, IL-6 and TNF-? with neutrophils and monocytes is present in CTO patients when compared with healthy subjects. Introduction: The findings of the research were introduced into the teaching process of Lugansk State Medical University. Sphere of application: Medicine, pathological physiology.