Areshkovich A. Pathogenetic basement of H2-histamine receptors and lipid peroxidation blokade efficacy at duodenal ulcer

The thesis is dedicated to the questions of pathogenetic basement of H2-histamine receptors and lipid peroxidation blockade efficacy at duodenal ulcer by examination of clinical, immune and metabolic parameters. The expression of apoptosis markers (CD95) and receptors for interleukin-2 (CD25) on immunocompetent cells of patients with duodenal ulcer is studied. Dynamics of changes of interleukins-1, -2, -4 and tumor necrosis factor a is investigated at duodenal ulcer. The condition of eucosanoid system and cyclic nucleotides in dynamics of disease is determined at duodenal ulcer. The clinical estimation of H2-histamine receptors and lipid peroxidation blockade efficiency is given at treatment of patients with duodenal ulcer. Influence of H2-histamine receptors and lipid peroxidation blockade on immune and metabolic parameters of patients is investigated at duodenal ulcer. Presence at patients with duodenal ulcer of metabolic homeostasis alterations, immune changes makes essential the use in complex treatment of famotidine and antioxidant a complex which have immune correcting and antioxidant action. The main outcomes of the research are used in practice of 2 hospitals of Kiev and Lugansk region. The obtained data are included in educational process of pathological physiology department of Lugansk State Medical University.