Sivash A. Homocystein and dyslipidemia in patients with chronic glomerulonephritis.

Object of the study: homocystein and lipids change in patients with chronic glomerulonephritis with various degree of kidneys function disturbances. Purpose of the study: optimization of diagnosis and prognosis of chronic glomerulonephritis courses on the basis of examination of plasmatic homocystein content and blood lipids spectrum. Methods of the study: there have been used general clinical methods of examination, there has been determined homocystein level, there has been studied the state of lipids changes. Practical significance: of the received data consists in substantiation of necessity to determine in all patients with chronic glomerulonephritis the level of plasmatic homocystein as well as the investigation in there patients the indeces of blood lipids spectrum. There have been picked out the criteria (hyperhomocysteinemia, dyslipidemia), and these allow to estimate the course of chronic glomerulonephritis, to prognoses the development of cardio-vascular complications and they can be usedfor chronic glomerulonephritis monitoring in all stages of diseases development. The results of plasmatic homocystein level determining and lipids spectrum indices can be the reason for pathogenic therapy of chronic glomerulonephritis correction. Novelty of the obtained results: there has been determined that the majority of patients with chronic glomerulonephritis of different degree of kidneys function disturbances have hyperhomocysteinemia of various extent of manifestation according to kidneys function impairment. For the first time there have been demonstrated that patients with chronic glomerulonephritis of IId and IIId degree with normal homocystein level have a more favorable course of disease than the patients with hyperhomocysteinemia. There has been determined that lipid change disturbances in patients with chronic glomerulonephritis of different degree of kidneys insufficiency consists in increase of atherogenic lipids fractions in blood. For the first time there has been determined an associatedparticipation of hyperhomocys-teinemia and dyslipoproteidemia in the development of cardio-vascular complications in patients with chronic glomerulonephritis with various degree of kidneys function disturbances, and positive correlative links between homocystein concentration and atherogenic lipids fractions in all patients with marked cardio-vascular complications are indicative of thes phenomenon. Introduction: the results of investigation are introduced into practice of Nephrology Department, Departmen of chronic hemodialysis of Kharkiv Regional Clinical center of Urology and Nephrology, of City Nephrology Consulting-Room, and Nephrology Consulting-Room of Out-Patient Department of Kharkiv Regional Clinical center of Urology and Nephrology. According to the results of investigation there has been received a patent for invention (№ 69759-А „Method of diagnosis of cardio-vascular complications in patients with chronic glomerulonephritis"). Sphere of application: medicine, internal diseases, nephrology.