Polyak O. The chemical and toxicological investigation of Loratadine

The thesis is devoted to the chemical and toxicological analysis of antihistaminic preparation Loratadine. The methods of the Loratadine identification have been offered, the conditions of quality Loratadine and some other antihistaminic preparations by the TLC and HPLC methods have been offered. Quantitations by the UV-spectrophotometry, extraction-photometry and HPLC of Loratadine and Dezloratadine have been worked out. The conditions of Loratadine and its metabolite extraction from aqueous solutions with organic solvents in dependence on pH medium have been studied. The comparative study of generally accepted in chemical and toxicological analysis extractive methods of substances from biological samples with respect to Loratadine has been carried out. The effective extractive methods of Loratadine from biological samples and biological fluids have been offered. On the basis of the carried out investigations the scheme of Loratadine chemical and toxicological analysis in extracts from biological samples has been offered.