Tkachuk O. Pathogenetic Principles of Neurochemical and Immunologic Dysregulation in Male Rats with the Syndrome of Prenatal Stress

A conclusion has been arrived at to the effect that stressor impacts during the prenatal period of ontogenesis essentially modify the reactivity of the thymus in response to the action of unfavorable factors. It has been made on the basis of studying the effects of prenatal stress on the system of cyclic nucleotides (cAMP and cGMP) in the thymus, the reaction of the structural-functional zones of the thymus of control and prenatally stressed male rats to immobilization stress according to the parameters of the intensity of lipid peroxidation, the activity of the enzymes of antioxidant defense, the intensity of monoamin fluorescence, changes of the lymphoid population structure, morphometric and densitometric characteristics of thymocytes. An investigation of the feedbacks between the thymus and neuroendocrine system carried out by means of a five day introduction of a complex of thymic peptides of T-activin has demonstrated that prenatal stress impairs the character of bilateral bonds between the serotonergic, ?-endorphinergic systems of the limbic-hypothalamic structures and thymic peptides, causes a prolonged modification of the feedback functioning in the system of the thymic peptides – hypothalamo-hypophysial-thyroid axis and intensifies the effect of thymic peptides on the prolactin secretion.