Ol'khovs'ka V. The peculiarities of hepatobiliar system lesions in pregnant women with preeclampsia and ways of their correction.

Object of the study: Preeclampsia. Purpose of the study: To optimize the diagnosis of the liver dam-age in pregnant, to determine the peculiarities of preeclampsia in-fluence on the functional and anatomo-morphological state of the liver, to work out complex therapy for preeclampsia with the use of plant flavonoids with a hepatoprotector effect. Methods of the study: Clinical laboratory, clinical instrumental, biochemical, immunomorphological, morphological, statistical methods were used. Practical significance of the obtained results. New information about typical morphofunctional disturbances in the liver in gestosis were obtained. Diagnostically significant parameters of the liver involvement to pre-eclampsia pathogenesis were determined, they can be used to evaluate the process severity, determine the necessity of hepatoprotective therapy and prognosis of the pregnancy outcome. A pathogenetically substantiated method of treatment for functional activity disturbances in pregnant with pre-eclampsia with the use of Piflamin was worked out, which allowed to improve the efficacy of preeclampsia treatment, promote a stable clinical remission, provided improvement of the state of the fetus and more favorable pregnancy outcome. Novelty of the obtained results: Based on retrospective pathological analysis, the study of the liver tissue from the women died from severe pre-eclampsia and eclampsia, typical lesions of the liver parenchyma which reveal some mechanisms of the liver involvement in gestosis were determined. For the first time, Doppler study of the blood circulation in the vessels of the liver was suggested for evaluation of its involvement in preeclampsia. For the first time, the possibility to use a plant polyflavonoid drug Piflamin as a hepatoprotector in pregnant with pre-eclampsia was substantiated. The advantages of the developed method for pre-eclampsia treatment vs the traditional methods of treatment were proven. Introduction: The findings of the research were introduced to the work of pregnancy pathology department and observation department of Kharkiv City maternity Hospital, maternity hospital No. 1, specialized maternity hospital No. 5, city maternity hospital No. 2 and 3 (Kharkiv). The findings of the research are used in the training process of perinatology department, obstetrics and gynecology department No. 2 of Kharkiv Medical Academy for Post-graduate Training, department of pediatrics, obstetrics and gynecology of medical faculty of Kharkiv National University named after V.N. Karazin. Sphere of application: medicine, obstetrics and gynecology.