Rubyns'ka T. The peculiarities of hepatobiliar system lesions in pregnant women with preeclampsia and ways of their correction.

Object of the study: Late gestosis. Purpose of the study: To improve the methods of pre-clinical di-agnosis and preventive treatment for late gestosis based on deter-mining the role of epiphysis and adenohypophysis in the etiopatho-genesis of late gestosis. Methods of the study: Clinical laboratory, instrumental, Doppler study, hormonal, and statistical methods were used. Practical significance: Scientifically validated new methods of early diagnosis of late gestoses and preventive treatment for this complication with the use of VITA-melatonin, which allows to make the course of the disease less severe and to prevent late ges-tosis, were worked out. Novelty of the obtained results: Based on the performed re-search, new aspects of pathogenesis of late gestosis in the form of functional deviations in the work of epiphysis and adenohypophy-sis as to melatonin content and ACTH were revealed, which al-lowed to optimize preventive treatment of the pregnant with a high risk of this complication. For the firsttime, functional deviations in the work of the hy-pophysis and adenohypophysis in pregnant with a high risk of late gestosis and complicated pregnancy were studied, which allowed to establish the changes playing a considerable role in diagnosis of preclinical forms of gestosis. For the first time, correlation of functional changes of the epiphy-sis, adenohypophysis and the changes in hemodynamics in the spi-ral arteries of the uterus as well as the changes of endocrine ho-meostasis were studied. Clinical, hematological, and hormonal efficacy of VITA-melatonin in complex treatment for gestosis was proven. Introduction: The developed method of early diagnosis of late gestosis was introduced into the work of gynecology out-patient departments of maternity hospital No. 1, out-patient hospital No. 10, out-patient department of hospital No. 1, hospital No. 12, ma-ternity hospital No. 5 (Kharkiv). A patent was obtained (Patent of Ukraine No. 62517 А "A method of pre-clinical diagnosis of late gestosis"). Sphere of application: Medicine, obstetrics and gynecology.