Verzhbyts'ka O. Clinical and Physiological Peculiarities of Migraine In Children and Teenagers.

In dissertation work the peculiarities of clinical picture and passing of migraine of children depending on the age and sex were determined. It was detected the certain intercommunication between the character of hemodynamic abnormalities and clinical variant of migraine. On basis of the complex comparative analysis of the electrical activity of the brain with usage of computer programs of the automatized amplitude-frequency analysis of electroencephalography (EEG), analysis of specific weight, topographic mapping and correlation analysis of the main frequency ranges the peculiarities of the spatial distribution and dynamics of activation focus, correlations in cortex of cerebral hemispheres which reflect the inter- and internalhemispheric interactions and corticosubcortical relations in case of migraine depending on the clinical form and period of the disease were determined. In the work the image of the role of limbic-and-reticular structures and internal-cortical interactions in case of the givendisease got the further development. One detected the unity of phenomenological manifestations of cerebral activity of the control mechanisms and the systemic organization in case of migraine and at the same time the differences of corticosubcortical and internal-cortical interrelations in case of different clinical forms and at the different periods of the disease are evinced. Analysis of the received results allowed to extend the image of pathogenesis of migraine, ascertain the peculiarities of passing of the clinical forms of children and teenagers' migraine, detect the character of electroencephalography and hemodynamic abnormalities at the different periods of the disease that contributes to the timely diagnostics and treatment of such patients.