Bolotova O. The chemical and toxicological investigation of ketorolac

The thesis is devoted to the chemical and toxicological research of preparation of group of nonsteroidal anti-inflammatory drugs (NSAID) - ketorolac. The results of ketorolac identification, by methods of IR- and UV - spectroscopy, TLC, HPLC, GLC and the conditions of its separation in the presence of other NSAID by the TLC and HPLC methods are offered. The sensible methods of quantitative determination of ketorolac are offered by the methods UV-spectroscopy, HPLC and GLC. The conditions of ketorolac extraction from water solutions by organic solvents depending on pH medium are investigated. Comparative study of isolation of ketorolac from biological material by the generally accepted in the the chemical and toxicological analysis methods are studied. The effective methods of isolation of ketorolac from biological material and biological fluids are offered. Distribution of ketorolac in the organs of the poisoned animals and keeping in biological material at its decomposition are studied. On thebasis of carried out researches the scheme of ketorolac chemical and toxicological analysis in biological material is offered.