Korotky Y. Synthesis and uterostimulating activity derivatives of 1-alkoxy-3-dialkylamino-2-propanole

The dissertation concerned with the synthesis and investigation of new aminopropanole derivatives. Interaction between 1-alkoxy-2,3-epoxypropanes and secondary amines afforded corresponding 1-alkoxy-3-dialkilamino-2-propanoles. Ring opening in 1-dialkylamino-2,3-epoxpropane by alcohols in the presence of Lewis acids was found as an alternative approach to the same alkoxy-aminopropanole derivatives. Numerous biologically active compounds bearing utherostimulating effect have been found. Some structure - activity relationships for such a type compounds were declared. The most effective 1-adamanthylethoxy-3-morfoline-2-propanole hydrochloride - ademol has unique combination of utherostimulating, analgetic, sedative and nootropic activities. Structural analogs of ademol were also prepared and exceeded the nootropic activity of test-drug piracetam in 1.4-1.7 times. Ademolwas recommended by Ministry of Health Defence of Ukraine as a oxytoxic.