Gisceva O. Pharmacognostic study of Rubus caesius leaves and formulation of medicines on its basis

For the first time the systematic photochemical and pharmacological study of the blackberry. The qualitative composition and quantitative content of the BAS of different groups in the raw material and medicines.16 individual compounds (2 derivatives of hydroxybenzoic acid, 6 derivatives of hydroxycinnamine acid, 8 - derivatives of flavonoids were isolated from the leaves of the blackberry and their structure was determined; 16 amino acids, 6 fat acids, 22 macro- and microelements were determined as well. For the first time the dynamics of BAS accumulation was studied: flavonoids in total, oxidizing polyphenols, ascorbic acid. The terms of raw materials stocking are determined.For the first time the capillary-strengthening, membrane stabilizing and haemostatic action of Rubus caesius leaves infusion (1:10) is studied, as well as haemostatic composition and dry extract. The lipophilic extract displays moderately expressed bacteriostatic activity with respect to gram-positive and gram-negative bacteria