Macidonska I. Peculitiaries of prevalence, diagnostics, clinical course of cosmetic dermatitis

The thesis is devoted to the study of characteristic featurea of clininical course, state of sensibilisation, cellular and humoral immunity, function of GIT and to the development of the metod of correction of diagnosed disorders in patients with allergic contact cosmetic dermatitis (ACCD). 61,5 % of patients had anamnestic family and individual record, clinical presentation is characterized by polymorfism and depend on the kind of cosmetic allergen, individual reactivity, acuity of process, pathological process has been localized in periorbital, perioral, parotid regions in 77% cases. 51% of patients had changes of immunity, wich is characterized by decrease of general level of T-cells, T-suppressor, IgА, IgG and increase of B-lymphocites, IgЕ. 30% of patients had pathlogy of GIT in form of gastritis B, gastroduodenitis and hepatobiliaru system - in form of chronic holecystitis and biliary dyskinesia. Patch testing was showed maximal sensibilisation to preservatives - paraben mix (25%) and formaldehyde (17 %), as well as to fragrance additions (23 %). Prescription of immunocorrectors Erbisol and Echinacea compositum S, sorbent Enterosgel, probiotic Bifiform against multimodality therapy allows to achieve positive results with 96,3% of patients, to reduce the term of treatment up to 11,2±1,5 days, to decrease the number of relapses up to 2,5 times as compared with the traditional treatment.