Shtoyko N. Synthesis of new tuberculostatic substances based on azolidine derivatives group and isonicotinic acid

Object - reactions of [2+3]-cyclocondensation in synthesis of 4-thiazolidones, interaction of thiazolidines with oxocompounds, reactions of azo-coupling and heterocyclization reactions; the purpose - synthesis of new substances based on the group of thiazolidine and izoniazide derivatives and search of effective and low-toxic physiologically active substances among them with antituberculosis and other actions; methods - organic synthesis, UV-, IR-, NMR-, chromatomas- spectroscopies, gas-liquid chromatography, traditional pharmacological screening; novelty - the effective methods of synthesis and transformation of thiazolidine derivatives with izoniazide moiety in positions 2,3,4 and 5-ylidenederivatives of fused thiazolotriazoles on the basis of izoniazide. Tuberculostatic activity of synthesized compounds have been studied, "structure-activity" correlations have been carried out and "lead-compounds" with high anti-inflammatory and antimicrobial activities have been identified; the outcomes - the row of new perspective and low-toxic compounds, which possess anti-inflammatory and antimicrobial action; certain criteria for the search of biologically-active compounds among thiazolidine derivatives have been formulated, especially with tuberculostatic action; there are introduced into scientific and educational process of pharmaceutical chemistry and organic chemistry departments of National Pharmaceutical University; area - pharmacy.