Doroshko V. Experimental Substantiation of the Role of the Sexual Hormones in the Cource of Ischemic-Reperfusion Brain Lesions in Rats of Diverse Age Groups

The dissertation deals with a study of age-related peculiarities of the neurochemical and biochemical mechanisms of the participation of the testicular sex hormones in the development of delayed after-effect of incomplete cerebral global ischemia in rats. In rats of two age groups the effect of ischemia-reperfusion on blood plasma progesterone and testosterone content, as well as the influence of castration on the postischemic parameters, the intensity of the catecholamine fluorescence, the state of lipid peroxidation, protein oxidative modification, the activity of the enzymes of antioxidant protection, fibrino- and proteolytic activity in the cortex of the frontal and occipital portions, hippocampal fields CA1, CA2, CA3 have been investigated. It has been corroborated that a postischemic decrease of the blood plasma progesterone and testosterone content in rats of diverse year classes has quantitative distinctions and is implemented via different mechanisms. It has been established that sex hormonesdeficiency brings on a considerable change of the reaction of the brain structures under study and ischemic-reperfusion lesions. Castration exerts a potentiating effect on age-specific distinctions postischemic intensity of catecholamine fluorescence and reducing effect on the processes of lipid peroxidation and protein oxidative modification.