L . Clinico-paraclinical characteristic and peculiarities of acute bronchitis course in children at the modern stage.

Object of the research:children with acute bronchitis Purpose of the research: to increase the effectiveness of early diagnostics and prognosis of acute persistent bronchitis on the basis of factors, clinical and paraclinical data, evaluation of physicochemical, cytological and immune features of bronchoalveolar lavage. Methods of the research: General clinical, instrumental, analytical statistical. Theoretical and practical findings:The development of a mathematical model for individual prognosis which can have an applied meaning in the prognosis of acute persistent bronchitis in children in out-patient and clinical practice in order to prevent it and its recurrence. The formations of three groups of dynamic observation was suggested depending on the risk of acute persistent bronchitis development. Novelty:Risk factors of acute persistent bronchitis were identified. It was recognized that the characteristic feature of acute persistent bronchitis in children is the morphological remodeling of tracheobroncheal tree macrophages and there functional inability in the background of moderate inflammatory changes. For the first time the presence of dysplastic changes of epithelial cells in children with acute persistent bronchitis was evidently demonstrated and their description in the classification-dependent manner was performed. It was identified that the greater number of patients has show an increased viscosity and more acidic reaction of the secretion. The interaction of the presence of abnormalities in the structure and dyskinesia of the bronchial tree which were revealed by bronchoscopy was proved. The interaction of factors, clinical data, endobronchial changes and specific features of bronchoalveolar lavage content in children with acute persistent bronchitis was identified. It was recognized that the bacterial study analyses of pernasal swabs and sputum is non-informative in patients with acute persistent bronchitis and it conditions the importance of bronchoscopical study for these children.A mathematical model of individual prognosis for acute persistent bronchitis in children was scientifically grounded and suggested. A method for evaluation of the local immunity dysfunction was developed; it cosists in the recognition of phagocytic and opsonic number of bronchoalveolar lavage macrophages in children. Degree of introduction: Тhe results of the study were administrated in the work of pulmonological, diagnostical departments and bronchoscopy room in Kharkov Regional Pediatric Clinical Hospital, Simferopol Clinical Hospital №2, Donetsk Central Hospital №6, Dnipropetrovs’k Pediatric Clinical Hospital №2, pediatric departments of Dvoritchansk, Bogoduchov, Sakhnovschina central district hospitals, which is confirmed by the respective, administration acts. The results of the study are used in the teaching process at the chair of Hospital Pediatrics at Kharkov State Medical University. Sphere of application: Medicine, pediatrics.