Drozd O. Comparative efficiency estimation of the different tocolytic therapy methods under preterm birth.

The dissertation is dedicated to actual in scientific and practical aspect of the subject - a reduction of the frequency preterm birth and perinatal losses on the account of the differentiated approach to tocolytic therapy. On the grounds of archive given studies it has been found out that frequency preterm birth for the period from 1996 till 2000 are presented by us has formed 7,7 percents. According to the electrophysiological studies results the influence of the above mentioned tocolytic medicines on on smooth muscle of human myometrium it was found out that Nifedipine, unlike Magnesium Sulfate and Hynipral has more vivid oppression on the myometrial smooth muscle cells. On the grounds of Dopplerografia data studies during tocolysis undertaking we came to the conclusion that Hynipral triggers better uterine-placental blood circulation, but it does not influence fetus hemodynamics. Magnesium Sulfate, in its turn, negatively influences all sections of uterine-placental-fetal circulation. Unlike thesemedicines, Nifedipine makes better uterine-placental blood circulation and positively influences fetus hemodynamics. The back proportional dependency of tocolytic efficiency of Magnesium Sulfate and Hynipral has been established with regard to the degree of preterm birth threat. Nifedipin has a high tocolytic efficiency. The differentiated approach has been worked out for tocolytic therapy of preterm birth threat of the pregnant who have different obstetric complications and extragenital pathology.