Shablykina O. 3-Hetaryl(aryl)coumarins and isocoumarins. Synthesis and properties

Coumarins with different heterocyclic substituents in third position of coumarin ring were synthesized. Further modification of 7-hydroxycoumarins was realized by alkylation, acylation and aminomethylation into eighth position of coumarin. Nitro group in 3-hetaryl- and arylcoumarins was transformed into amino and acylaminogroups.3-Нetаryl(aryl)isocoumarins were synthesized by condensation of hetaryl(aryl)carbonyl chlorides with homophthalic acid at high temperature or with homophthalic acid anhydride at basic catalysis. Reaction between hetaryl(aryl)carbonyl chlorides with homophthalic acid monoesters gives 3-hetaryl(aryl)-4-carboethoxyisocoumarins. 2-(Oxo-2-hetaryl(aryl)ethyl)benzoic acids and 3-hetaryl-1,2-dihydro-1-isoquinolones were synthesized by using of 3-hetaryl(aryl)isocoumarins.