Petrushova L. Synthesis, chemical and biological properties of 1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids thiazol-2-yl amides

The synthesis of a big class of 1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids thiazol-2-yl amides and their halogen-substituted analogues in the benzene ring of the quinoline nucleus has been carried out with the aim of the further biological research. It has been experimentally found that water determines the bromination direction of ethyl 1-R-2-oxo-4-hydroxyquinoline-3-carboxylates by a molecular bromine. Its presence leads to 3-bromoderivatives while after dehydration of the solvent and reagents 6-bromosubstitued isomers have been formed. The microbiological screening the substances synthesized has been conducted. 1-Octyl-2-oxo-4 hydroxyquinoline-3-carboxylic acid thiazol-2-yl amide has been recommended for profound research as promising drugs suitable for treating tuberculos