Naumko R. Pathochemical changes in arteries and veins as factors of developing their adrenaline injury

The thesis is devoted to the experimental researching of lipid peroxide oxidation (LPO) role in the development of blood vessel arteriosclerosis under conditions of hyperadrenalinaemia. The injection of elevated doses of adrenaline (50 mkg/kg) to rabbits during 14 days has showed that the increase of inulin space volume, water content percentage, calcium level and products of LPO are more intensive in arterial tissues than in venous tissues. It has been established that the decrease of antioxidant enzyme activity (glutationperoxidase, superoxiddismutase, catalase) in arterial vessels of rabbits is characteristic of the development of adrenaline injuries in these arterial vessels, while in venous wall the activity of these enzymes increases. The more intensive antioxidant activity of venous tissue can be one of the causes of the greater resistance to catecholamine injures in veins than in arteries. The injection of elevated doses of adrenaline (50 mkg/kg) to rats during 14 days has showed that the increase of water content percentage, calcium and magnesium level are more intensive in aorta tissues, than in back hollow vein tissues. The content of copper, zinc, iron and manganese, on the contrary, increases more actively in venous tissues, while the content of iron and manganese in aorta tissues generally decreases. The achieved results may indicate the more intensive adrenaline injuries and less active protective and compensative reactions in the arteries of rats than in their veins. Vitamin E, which reduces content of products of LPO and restricts the injuries of blood vessel wall in rabbits (reduces inulin space volume and water content percentage), is established to reduce the content of calcium in the vessel wall as well. At the same time, nifedipine reduces both the content of calcium and the indices of blood vessel wall injuries more actively, than vitamin E does. Thus the conducted experimental researches may signify that, in the case of injection of elevated doses of adrenaline to animals, the accumulation of calcium in vessel tissues causes more intensive injuries of blood vessels than the accumulation of LPO does.