bject of research: renoparenchymatous arterial high-blood pressure. Рurpose of the research – improvement of diagnostics and medical treatments of patients with renoparenhimatous symptomatic arterial high-blood pressure on the basis of finding of role of cytokines, determinations of violations of lipid metabolism, which led to formation of immune complexes, which contain of low density lipopro-teins and their intercommunications in the development and progress of symptomatic arterial high blood pressure and estimations of influence on these indexes of the combined therapy by antigypertenzion facilities and statins. Methods of research: clinical and laboratory, іmmunoenzyme assay, enzime kolorimetric, statistical. The practical importanse of the received results consists of the ground of necessity of determination of pro- and antiinflammatory cytokines, violations of lipid metabolism and level of immune complexes, which contain of low density lipoproteins at patients with renoparenhymatous arterial high-blood pressure. The study of changes interleykin-1? and -10 allows to improve estimation of prognosis of disease. Research of lipid metabolism allows more adequately and pick up to full therapy, and control its efficiency. The study of changes of lipid immune complexes allows to control the dynamics of the state of the immune system in the process of medical treatment. Medical treatment of patients by the combined therapy by ingibitor of angiotenzinconverting enzyme, by the antago-nists of ions of calcium, statins (simvastatin) allows to promote efficiency of medical treatment and accelerate the terms of receipt of positive results. Scientific novelty of the received results. Patients with renoparenhymatouz arterial high-blood pressure were had exposed violations of lipid metabolism, as a rise of level of general cholesterol, general triglitserides, cholesterol of low density lipoproteins and atherogenic coefficient on a background the decrease cholesterol of high density lipoproteins. It is set, that theseviolations were led to formation of immune complexes, which contain of low density lipoproteins that is confirmed by the presence of positive correlation communications between the indicated indexes of lipid metabolism and LDLP-IgA, LDLP-IgG. The features of change of maintenance of immune complexes, which contain of low density lipoproteins at renoparenhymatous arterial high-blood pressure are exposed, which consist in the statistically meaningful rise of the LDLP-IgA level and reduction of the LDLP-IgG level. It is set, that the immunoinflammatory mechanisms of development of renoparenhymatous arterial high-blood pressure are characterized by activating of cytokines link of the immune system: statistically meaningful increase of level both interleykin-1? and interleykin-10. In rising degrees of arterial high-blood pressure a level interleykin-1? statistically going down. It is set, that cooperation of metabolic and immune factors make to development and progress of renoparenhymatous arterial high-blood pressure which is confirmed by the exposed positive correlation communications between interleykin-1? and level of general cholesterol, triglitserides, cholesterol of low density lipoproteins, atherogenic coefficient, LDLP-IgG, by day's proteinuria, by negative correlation communication between LDLP-IgG and day's proteinuria. It is shown, the combined medical treatment by ingibitors of angiotenzinconverting enzyme, antagonists of ions of calcium and statins patients with renoparenhymatous arterial high-blood pressure has a positive influence not only due to reduction of atherogenic lipoproteins, but also pleotropiс action of statins, which showed up in the decline of level of pro- and antiinflammatory cytokines, reduction of day's proteinuria. Degree of introduction: The results of research of introduced in practice inspection and medical treatment of patients in therapeutic and nephrology separations of city clinical hospital № 26 of Kharkov, in ambulatory clinic of family doctor MGK “Internationalist”. Sphere ofapplication: medicine, therapy.
