The investigation object: chronic inflammation at action of low dose-rate gamma-radiation.. The investigation goal: finding out of the cellular and humoral hematological mechanisms of inflammation chronization, substantiation of hemomodulator application for prophylaxis and treatment of chronic inflammation. Methods of research: pathophysiological, histological, immunohistochemical, physicochemical, cultural, cytological and statistical. The theoretical and practical importance of the received results: Obtained results expand existing ideas of effectors and mechanisms of low dose-rate gamma-radiation effects, in particular, at chronic inflammation, and, thus, are of great importance for pathophysiology and radiobiology. Cellular reactions and radiation doses at which the highest risk of carcinogenesis takes place at chronic inflammation are determined. They can matter for revealing of risk groups among the persons living on radiation polluted territories and working at increased level of background radiation. The scientific novelty of the investigation results: Peculiarities of cellular reactions of the chronic inflammation focus at action of low dose-rate gamma-radiation in a wide range of doses, in particular, the immediate and delayed radiation effects in inflammation dynamics, dose dependences of DNA damage and also the activity of prooxidative and antioxidative systems are investigated. At that the conditions of activation of p53 genome stability system in different types of inflammatory cells are determined. It is shown, that at the certain doses and cellular reactions discrepancy of the level of p53 genome stability system activation and DNA damage is observed. Dose dependencies of cell content of the chronic inflammatory focus are revealed. Mechanisms of interaction between chronic inflammation and irradiation are proposed. Exposure doses and cellular reactions at which the oncogenous potential of chronic inflammation is fulfilled to the utmost are determined. The degree of implementation: the results of the research are implemented in the educational process at departments of pathophysiology of Kharkov, Bukovin, Donetsk, Lugansk, Odessa, and Ternopol State Medical Universities. Branch of usage: medicine, pathophysiology, radiobiology, radiation medicine, oncology.
