Goncharov Y. Specific effects of bloodletting and erythrocytapheresis on the clinical course of Polycythemia Vera in the erythremic stage.

The dissertation take great care to study of the specific effects of bloodletting and erythrocytapheresis on the clinical course of Polycythemia Vera in the erythremic stage. The obtained data shows that erythrocytapheresis decreases the count of erythrocytes, concentration of hemoglobin, value of hematocrit and arterial pressure more effectively, and improves the functional status of myocard in patients with PV more effectively than bloodletting. It has indicated a decrease of platelet adhesive and aggregation properties, and fibrinogen concentration both after bloodletting and after erythrocytapheresis. It was identified that blood exfusion using ticlopidine reduces adenosinediphosphate-induced platelet aggregation properties more significantly than the use of aspirin. It reduces the frequency of thrombohemorrhagic complications, and side effects occurrences less frequent than those related to bloodletting. The results of this study allowed to develop indications for performing bloodletting and erythrocytapheresis in patients with PV based on hematocrit value, concentration of hemoglobin and erythrocyte count in peripheral blood and existence of arterial hypertension.