Timofiichuk I. Age-related specific characteristics of ischemic-reperfusing reorganization of the catecholaminergic systems of the brain limbico-hypothalamic structures and stress-reactivity in male rats

The dissertation presents the findings of investigating the hormonal, neurochemical parameters of the functional state of the system of stress-realization and stress-limitation in one- and three month old male rats with incomplete global cerebral ischemia and effect exerted on these parameters by the Emoxipin remedy. Аt a later stage of the postishemic period the reaction of the hormonal indices of stress-reactivity is preserved, whereas in three month old animals there occurs its exhaustion. The age-related peculiarities of the cerebral manifestation of stress-reactivity consist in a more considerable decrease in the limbico-hypothalamic cerebral structures of tree-month old rats of the catecholamine fluorescence intensity, the most essential disturbans of the indices of lipid peroxidation and antioxidant defense, as well as in the most extensive structural changes of the content of the oxidative modification of proteins and the parameters of the fibrinolytic activity. The effect of Emoxipin on the pathogenetic components of the ischemic-reperfusing damage of the brain also depends on the age of animals. The mechanisms of stress-reactivity, activated under conditions of cerebral ishemia in one month old rats are not completely formed and undergo further ontogenetic changes and a correction of their disturbances requires taking into consideration the age of animals.