Gasyuk N. Clinical-morphological aspects of primary defeats of lungs at the prematurely born children

Object of the study: primary defeats of lungs of uninfectious genesis at the prematurely born children. Purpose of the study: the optimization of the care of prematurely born children with respiratory distress-syndrome by research of embryogenesis of lungs, peculiarities of patho-morphogenesis of hyaline membrane disease and analysis of factors of risk of prenatal ontogenesis, which influence on heavy motion of the given pathology. Methods of the study: general clinical, laboratory, instrumental, morphological and statistical methods. Practical significance of the obtained results: consists in reliable estimation of morbidity and mortality of the prematurely born children with respiratory disorders. With the purpose of prevention of development of the given pathology the necessity of removal of definite factors of perinatal risk is proved. It is improved the diagnostics of respiratory distress-syndrome at the prematurely born children by the selection of separate patho-morphological forms of hyaline membrane disease. The most important factors of perinatal risk and their coefficients of correlation of chances which can be used for prognostication of heavy motion of the given pathology and possibility of lethal outcome are determined. Novelty of the obtained results: epidemiology of respiratory disorders is first explored at the prematurely born children in the Poltava region and the main tendencies of morbidity and mortality are revealed. For the first time the clinical-morphological approach for clarification of separate links of pathogenesis of primary defeats of lungs at the prematurely born children is applied. The role of immaturity of parenchyma-vascular component of lungs in development of respiratory distress-syndrome is shown. The typical morphological changes in lungs are revealed, depending on gestation age of child. The role of aspiration syndrome in the peculiarities of motion of respiratory distress-syndrome at the prematurely born children is definite. The reliable factors of risk, to whichdevelopment of the given pathology is related at newborns, and factors, which most substantially influence on heavy motion of the given pathology and its consequence are definite for the first time. Degree of introduction: the results of researches are included into the practical activity of departments of intensive therapy of newborns (Poltava, Kiev, Zaporizhya). The results of patho-morphological researches are included into the work of practical pathologists of Poltava. General theoretical and practical positions of the dissertation work are used in an educational process on the department of faculty pediatrics with neonatology of Ukrainian medical stomatological academy of MHC of Ukraine, Poltava.