Irynchyn G. Multimodality Treatment of Patients with Acne Vulgaris, Using Antioxidant Complex and Combined Laser therapy

The dissertation deals with bringing up-to-date modes of treatment of patients with acne vulgaris on the basis of studying the parameters of systemic immunity as well as pro- and antioxidant blood system. The clinic-epidemiological specific characteristics of acne vulgaris and their influence on the psychoemotional condition of patients have been ascertained. The availability of secondary immunodeficiency according to the cellular type, a decrease of the phagocytic activity of phagocytes, as well as the formation of the state of endogenous intoxication against a background of a lack of antioxidant factors found to be interdependent with the degree of the severity of the clinical course of acne vulgaris have been established. Experimental substantiation of the presence of the bactericidal action of low intensity laser radiation on the bacterial flora that persists at the site of pustular acne rash has been carried out. A new mode of holiatry of patients afflicted with acne vulgaris with the use of the antioxidant complex Tri-V Plus and combined laser therapy (transcutaneus laser radiation of the blood and laser photophoresis) has been elaborated and introduced in medical practice. It has become possible to shorten the terms of treatment by 5-6 days, to achieve a decrease (1,7 times) of the number and the marked character of relapses in a year and a prolongation (2,5-3 months on the average) of the duration of the state of remission of dermatosis against a background of the normalization of the parameters of the above-mentioned systems of the patients' organism.