Basok O. Clinical significance of interleukins and immune response in chidren with salmonellosis.

Object of the study: children with salmonellosis infection. Purpose of the study: improving methods of diagnosing and forecasting development of children’s salmonellosis infection on the base of quantification study of interleukines and immune response. Methods of research: Clinical methods of examination, bacteriological, serological, instrumental, immunological and statistical methods. Theoretical and practical results: it is proved alongside with the standard complex of inspection at a hospital stage research of the contents of interleukins and parameters cellular and humoral immunity with the purpose of definition of activity, an estimation of severity and a direction of current of pathological process. On the basis of revealed informative of anamnesis, clinical and laboratory and immune parameters it is developed a prognostic method which is offered to introduction in practical activities. Use of it allows doctors in conditions of a hospital with high reliability to predict current of asalmonellosis at early aged children that allows to lead in due time in case of expected adverse current individually directed correction of therapy of patients. It is offered for an objective estimation of the data on completeness of recovery to keep up dynamics of interleukins: their high level before an extract from a hospital testifies about preservation of inflammatory reaction, namely – continuation of illness. It should be taken into account during a substantiation of a complex rehabilitation. Novelty: are specified clinical current and features of immune reaction of children of early age depending on the contents interleukins in blood that has allowed to expand representations about pathogenesis of salmonellosis. For the first time are investigated intrasystem and intersystem interrelations between levels interleukins, parameters of immunity and peripheral blood at various variants of illness. The analysis of results of research has allowed revealing two types of functioning of system sanoginesis: normal reactivity and hyper reactivity with deficiency of compensation. The great comprehension in prognosis of salmonellosis development was revealed with immune criteria in comparison with anamnesis, clinical and laboratory symptoms Among immune parameters the first place occupy interleukins, the following – cellular immunity, and then – humoral immunity. Degree of introduction: results of research are introduced into practice of children's hospitals of public health services of Ukraine, namely: the Kharkov regional children's infectious hospital, 1-st children's polyclinic of Kharkov, infectious branch to Donetsk regional children's clinical hospital, and clinical infectious hospital of Lvov city. The received data are used in educational process of the Kharkov state medical university, the Kharkov academy postgraduate education, Donetsk state medical university, the Lvov national medical university. Sphere of application: Medicine, children infectious disease.