Kichimasova Y. Pharmacognostical study of ash tree (Fraxinus excelsior L.) and development of substances on its basis.

For the first time in Ukraine systemate pharmacognostical stady of ash tree (f. excelsior) raw material has been carried out and worth-while development on its basis medicinal forms of various actions has been shown. It has been established that leaves and bark of ash tree are worth-while kinds of raw material. 19 substances have been extracted from its leaves and bark in individual state. 4 substances have been extracted from ash tree leaves the first time. 5 substances have been extracted from ash tree bark for the first time. Quantitative content of fatty acids, macro- and microelements, ascorbic acid, sum of organic acids and series of phenolic compounds in raw material and substances of ash tree have been established for the first time. Technological parameters of raw materials have been distinguished, optimal technologies for receiving dense extracts of leaves and bark of ash tree have been developed, indications of raw material and received substances needed for standardization have been established. It has been distinguished that received substances show antimicrobial, citotoxic, membrane stabilizing, spermicidal action, increase cell immunity. Project of analytical nominative documentation for bark and dense extract of bark have been developed for the first time. Technological time-limit for receiving of dense bark extract of ash tree.