A research object - white non thoroughbred laboratory rats-males, that was experienced by action of mainly explosive contusion, or burn, or also poisoning by explosive gases on a background of previous action of industrial factors, or without such action; purpose - to discover early disorders of cerebral hemodynamic at separate action of the components of mine explosion and to determine pathogenetic dependence of these disorders both from disorders of system hemodynamic and previous action of industrial factors; methods - electro-physiology, instrumental, mathematical, statistical; novelty - for the first time it is established that at the initial stage of contusion, and burn, and toxic mine defeat there are considerable disorders of cerebral hemodynamic, and circulatory hypoxia develops, and it become impossible to supply the brain with oxygen as a result of decreased stroke volume, and minute volume, and also of systolic volume of cerebral circulation, and minute volume of cerebral circulation; forthe first time it is proved that on a background of previous prolonged modelling of complex of mine industrial factors on an organism of a rat there are more deep disorders of cerebral hemodynamic at an initial stage of separate action of the above mentioned components of mine explosion, than at a non burdened exrposive mine lesion; for the first time it is got findings about the origin of dependence of the disorders of cerebral hemodynamic from the state of system hemodynamic both at the burdened contussion and burn explosive mine trauma; for the first time it is shown that compensatory possibilities of an organism in relation to cerebral hemodynamic exercise in lesser degree than to system hemodynamic at the burdened toxic mine lesion; results - the determined disturbances of cerebral hemodynamic at an initial stage of action of either components of mine explosion on an organism it is expedient to take into account at planning of a programm of critical care; it is expedient to assume the established dependence of coming disorders from presence of preliminary influence of premorbid industrial factors at action of either components of mine explosion as a basis of medical sorting of victims; information about the features of changes of systolic, and minute volume of cerebral circulation of blood, and also of cerebrovascular resistance at action of either components of mine explosion it is expedient to take into account at elaboration of optimal methods of correction of the investigated disorders; it is inculcated at educational process - both at a lecture cource and practical training, and also is used at experimental scientific researches at the departments of athological Physiology; Combustiology, Plastic Surgery, and Urology; Traumatology, Orthopedy, and Military Surgery; Military Medicine Department; Pathophysiology Department of The Research Institute of Traumatology and Orthopedy of Donetsk State Medical University Named After M. Gorki, and at the Departments of Pathological Physiology of Zaporozhian, and Lugansk, and Odessa, and Kharkov, and Crimean State Medical Universities; sphere of use - medicine (pathological physiology).
