Bolokadze Y. Role of matrix metalloproteinases in the processes of myocardium remodeling development and energy dysmetabolism in metabolic syndrome.

Object of the study: metabolic syndrome. Purpose of the study: optimisation of heart affection diagnostics in metabolic syndrome on the basis of myocardium structure-functional models in relationships with matrix metalloproteinases-1 levels and disorders of energy balance investigation. Methods of the investigation: clinical, biochemical, immunoenzyme, radioimunological and instrumental methods were used. Theoretical and practical results: the data received at studying of combinations of components of a metabolic syndrome and their influence on structurally functional reorganization of a myocardium can be used in the further for definition of mechanisms of remodeling a left ventricle myocardium. It is established, that at patients with 4 componential metabolic syndromes the most adverse clinical current of disease, formation concentric, eccentric hypertrophies of a left ventricle myocardium is observed. The opportunity use value of matrix metalloproteinases-1 and tissue inhibitors of matrix metalloproteinases-1 as markers of myocardial fibrosis that will promote improvement of diagnostics of remodeling process a myocardium at patients with a metabolic syndrome is finished. It is shown, that these changes are connected with parameters of left ventricular mass index and end-diastolic diameter. It testifies to presence of communication between levels of matrix metalloproteinases-1 and tissue inhibitors of matrix metalloproteinases-1 formation of the certain type of myocardium remodeling. The orientation of changes in energy metabolism at patients with a metabolic syndrome can be used as indicators of purpose of metabolic therapy, and their dynamics should be observed for definition of terms of treatment.Novelty: the role of system of matrix metalloproteinases-1 and tissue inhibitors of matrix metalloproteinases-1 in processes of extracellular matrix remodeling of myocardium, its communication with energy metabolism at patients with a metabolic syndrome is investigated. The analysis of interrelations between levels of remote fibrosis markers and in ultrasound parameters at patients with various components of a metabolic syndrome is lead. Dependence between quantity of attributes of a metabolic syndrome and qualitative reorganization of a myocardium is established. By comparison of parameters of matrix metalloproteinases-1 and tissue inhibitors of matrix metalloproteinases-1 with ultrasound parameters, their close interrelations are revealed. It is certain of energy dysmetabolism exchange of a myocardium at patients with different types of left ventricle remodeling at a metabolic syndrome. Features of infringements of a energy metabolism exchange of a myocardium at patients with a metabolic syndrome and an arterial hypertension with metabolic infringements are certain. Degree of introduction: the results of the research were introduced into the work of therapy departments of city hospital No. 1, 3, 11 (Kharkiv), city hospital (Balaklea and Bogoduchov, Kharkiv region). 1 patent of Ukraine is received. Sphere of application: medicine, therapy and cardiology departments.