Object of the study: Metabolic syndrome and chronic heart failure due to coronary artery disease. Purpose of the study: To improve the treatment of CAD with CHF with metabolic syndrome basing on the study of structural functional parameters of the myocardium, inflammatory mechanisms (TNF?, IL-1?, IL-8), lipid and carbohydrate metabolism, their influence on the level of ACE inhibitors (lisinopril, enalapril), statins (lovastatin). Methods of research: General clinical, anthropometry, instru-mental, immunoradiometry, immunoenzyme, statistical. Theoretical and practical results: The performed investigation demonstrated the importance of the study of cytokines as well as the indices of carbohydrate and lipid metabolism for timely and qualitative diagnosis in CHF combined with metabolic syndrome, which is of great importance for atherosclerosis prevention. The obtained findings promote an adequate use of combination of some drugs with the purpose to improve the functional state of the myocardium in patientswith CHF with MS. Based on the performed research, approaches which allow improvement of the scheme for treatment of the patients of patients with CAD complicated with CHF with metabolic syndrome and to reduce the risk of further CHF progress, were suggested. Novelty: It was determined that structural functional changes in the LV myocardium in patients with CHF with metabolic syndrome manifested by its remodeling accompanied by early diastolic myocardium dysfunction, namely relaxation disorders and pseudonormal type, which promotes further progress of CHF. It was proven that significant difference of EDV, EF, LVPWT in patients with CHF with MS and in the group without MS, suggested the role of MS in disorders of LV systolic function. Significant difference in ESV, EF, LVMM (p<0.05) was established in patients with CHF and MS depending on the degree of carbohydrate metabolism impairment .It was shown that CHF development in patients with MS was realized with pro-inflammatory cytokines participation. Positive association between their amount and CHF FC was revealed. The influence of complex application of ACE inhibitors (enalapril, lisinopril), statins (lovastatin), metformin and glybenclamide on the func-tional state of the myocardium, cytokine link activity, lipid and carbohydrate metabolism parameters at CHF and metabolic syn-drome was proven. Degree of introduction: The findings of the research were in-troduced to the work of therapy and cardiology departments of Sumy Regional Hospital for was invalids, Sumy City Hospital No. 1, Sumy Regional Hospital, Sumy Regional Hospital for Ra-diation Protection, Trostianets Central District Hospital, Kras-nopolskaya Central District Hospital, Kharkiv City Hospital No. 27 as well as teaching process of Internal Diseases Department of Sumy State University. The materials of the dissertation were used to prepare Informa-tion Letter No. 41, 2005 (Issue 3, Therapy) “The use of Lovas-tatin in complex treatment for coronary artery disease with meta-bolic syndrome in elderly patients”. Sphere of application: medicine, internal diseases.
