Kul'bachuk A. Features of endotheliumdependet infringements of hemostasis' anticoagulant part and possibility of their correction by application of perindopril in complex therapy of patients with stable stenocardia.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0407U000075

Applicant for

Specialization

  • 14.01.11 - Кардіологія

15-12-2006

Specialized Academic Board

Д 52.600.01

Essay

Object - state of endothelium's vasomotor, anticoagulant and fibrinolysisregulate functions in patients with stable stenocardia; methods – clinical, instrumental, laboratory (protein C, antithrombin III, plasminogen activator ingibitor – 1, plasminogen), statistical; novelty - for the first time endothelium's functional possibility was analyzed at the time of veinocclusion test concerning counteraction of hypercoagulation in patients with stable stenocardia; understanding of stable stenocardia's pathogenesis was extended because of explanation of endothelium's anticoagulant and fibrinolysisregulate functions; perindopril's effectiveness was demonstrated concerning improvement of endothelium's vasomotor, anticoagulant and fibrinolysisregulate functions in patients with stable stenocardia. Results - improve of treatment effectiveness of patients with stable stenocardia because of correction endothelium's anticoagulant and fibrinolysisregulate functions by application of perindopril in their complex therapy; branch – medicine.

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