Shysh A. Investigation of cardioprotective mechanisms of plant-derived omega-3 polyunsaturated fatty acids on myocardium damage of different genesis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0407U000564

Thesis Registration Form

0407U000564.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

16-01-2007

Specialized Academic Board

Д26.198.01

Essay

It was shown that addition omega-3 PUFA both of marine origin and plant-derived to the animal diet within 4 weeks resulted in change of cell membrane fatty acid composition namely raising the level of omega-3 PUFA and reducing the level of omega-6 PUFA in membrane of myocardium. The main factors of higher resistance of the heart to pathological influence after membrane composition modification by omega-3 PUFA are following: 1) inhibition of oxidative and activation of antioxidative processes; 2) minimization of heart and vessels reactivity to adrenergic stimulation; 3) the release inhibition of AA and its metabolites leukotriens and tromboxanes; 4) positive changes in NO-system.

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Files

Dys.doc

aref.doc

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