Pishchulina S. The role of calcium homeostasis violations in pathogenesis of systemic hemodynamics disoders in the acute period of traumatic disease

Object of the investigation - 214 white rats-males with a trauma by Kennon model in the modification Shtykhno Y.N., 50 control and 10 intact animals; aim - to establish the pathogenetic role of calcium homeostasis violations in forming of systemic hemodynamics disorders for prognostication traumatic disease acute period; methods - physiological, biochemical, immunoenzymological,radioimmunological and statistical; novelty and results - it was firstly complex valuation of calcium homeostasis in the acute period of traumatic disease; three types of calcium homeostasis violations was detected: hyper-, eu- and hypocalcaemia; it was set that the reaction of calcium-regulatoryu hormones lay in basis of forming of calciemia types: the considerable prevalence of parathyroid hormone levels over calcitonin stipulated the development of hypercalciemia, the unidirectional reaction of both hormones provided support of calcium levels in blood within the limits of norm (eucalciemia), a hormonal disbalance and substantial increase of calitonin compared to parathyroid hormone stipulated the hypocalciemiacal reaction; first the intercommunication of violations of calcium homeostasis and reaction of the hypophysarno-thyroid system was shown; it was established, that alternate violations of calcium homeostasis lie in basis of disorders of systemic hemodynamics; the dependence between weight of flow of traumatic disease and state of calcium homeostasis was determined by the method of multifactor correlation and regressive analysis; and also the criteria of prognosis of acute period of traumatic disease results was developed; it was introduced - in training course at departments of pathophysiology of medical universities in Donetsk, Zaporozhye, Odessa, Lugansk, Bukovina, department of anesthesiology, intensive care and critical state medcine and department of traumatology and orthopedy in Donetsk State medical university, at practice of Institute of urgent and restoring surgery (Donetsk), Research Institute of traumatology andorthopedy in Donetsk State medical university; scope of use - educational process of medical university, diagnostic and medical process of traumatology and anesthesiology department.