The investigation object: mechanisms of chronic inflammation in the conditions of action of low dose-rate ?-radiation. The investigation goal: definition of influence of low dose-rate ?-radiation in different doses on blood system at chronic inflammation. Methods of research: pathophysiological, cytomorphological, cytochemical, statistical. The theoretical and practical importance of the received results: : the results extend existing views about effects and mechanisms of action of low dose-rate ?-radiation, particularly in chronic inflammation and thus are important for pathophysiology and radiobiology. They can be used for teaching, further scientific and research work, and taken into account while improving principles of radiation effects prevention, and pathogenetic treatment of chronic inflammatory diseases and action of ionizing radiation. The scientific novelty of the investigation results: for the first time influence of low dose-rate ?-radiation on blood system at chronic inflammation was studied. It was established that influence of ?-radiation on all parts of blood system in inflammation (inflammatory focus and peripheral blood leukocytes, bone marrow hemopoiesis) was significant not only in doses 1 Gy, but also in small (0,1 Gy) and intermediate (0,5 Gy) doses. It was found out that low dose-rate ?-radiation in above mentioned doses caused stimulation (gormesis) of chronic inflammatory focus, hemopoiesis and functional activity of peripheral blood leukocytes. It was shown that gormesis was characteristic not only for 0,1 Gy, but even for 1 Gy and 0,5 Gy, maybe because of low intensity of irradiation. At the same time it was found out that hormesis was more expressed in the dose of 0,1 Gy. Immediate and delayed effects of low dose-rate ?-radiation on blood system reactions in chronic inflammation, dependence of the effects from irradiation doses, cell types and terms of inflammation were shown. The degree of implementation: results of the research were implemented into the educational process atdepartments of pathophysiology of Kharkiv, Donets'k, Crimean, Lugansk, Odesa State Medical Universities, Sumy State University, Dnipropetrovs'k State Medical Academy and Ukrainian Medical Stomotological Academy, Poltava. Branch of usage: medicine, pathophysiology, radiobiology, radiation medicine, oncology.
