Pisotska O. The role of structural functional changes of an internal carotid artery wall in pathogenesis of atherothrombotic stroke

The dissertation is dedicated to determine the role of structural functional changes of an internal carotid artery wall in pathogenesis of atherothrombotic stroke with the purpose of working out treatment and preventive measures directed to decrease the risk of development of recurrent cerebral stroke. On basis of clinical, CT, Doppler and biochemical examination data in 98 patients with atherotrombotic stroke we defined the main risk factors and added the diagnostical criteria of this subtype of stroke. The investigation carried out showed that the main pathogenetic mechanisms of development of atherothrombotic stroke are a hemodynamic one which lies in reduction of blood circulation distant by from the stenosis and a mechanism of artherio-arterial embolism. It was determined and analyzed correlation of thickening intima-media complex of internal carotid artery with structure of a level of carotid stenosis, a level of cholesterol and coronary atherosclerosis. The data were obtained regarding the roleof atherosclerotic plaque in the development of cerebral stroke. Mechanism of artherio-arterial embolism and development of neurologic symptomatics was proved to primarily depend on atherosclerotic plaque structure. Key words: artherothrombotic stroke, internal carotid artery, atherosclerotic plaque, pathogenetic mechanism, intima-media complex, stenosis.