Dunaevka O. 3. Influence of immunostimulators on immune bodies of dogs in radioactive contamination condition

The histological, histochemical, morphometrical, radiological researches of thymus, lymphouodes (mandible and superficial cervical), spleen of dogs of age groups (2 month and 2-6 years old) after the influence of immunostimulators are proved. In immune organs and peripherical blood of dogs with were in radionuclide contaminated land, the definite changes discovered: decreasing of lymphoid tissue place, decreasing of immunoglobulin level, deflection of values of absolute and relative morphometrical indexes, these organs in complex can lead to development of secondary immunodeficient status. Histostructure im-munocompetentive organs immune system, after using of immunostimulators is not chanoed. In-creasing of relative place of cortex in of thymus, lymphoid tissue of lymphonodes, white pulp of spleen are observed, in blood serum the concentra-tion of immunoglobulins and phagocytes activity are increased. The tendency to immunogenesis are stored in dogs of both age groups of radionuclide contaminated land, but it not reached the level of control animals.