Hefter Y. Clinical-diagnostic and pathogenetic importance of polymorphism of I type angiotensin receptor gene and B- natriuretic peptide in patients with hypertonic disease who were afficted with myocardial infarction and cerebral insult.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0407U002847

Thesis Registration Form

0407U002847.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

07-06-2007

Specialized Academic Board

Д.26.003.08

Essay

Dissertation is devoted to studying of the role of polymorphism of AT II receptor of the first type, changes in function of vascular endothelium and concentracion of B-natriuretic peptide in the development and the course of hypertonic disease. It was established that presence of C allele in genotype of the 1st type angiotensine II receptor in residents of town of Vinnytsa and Vinnytsa region is associated with morbility of hypertension. Allele C is determited to correlate with the marked pathologic changes in the condition of the heart and vascular endothelium. Plasma level of B-natriuretic peptide is defined by diastolic disfunction, pronounced degree and excentric character of hypertrophy of left ventricle.

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Files

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dis1.doc

dis2.doc

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