The object is patients with background precancerous diseases and with cervix uteri cancer. The objective is to define the endogenous interferon role, the apoptosious index and the factor of integration of human papilloma virus (HPV) during cervix uteri cancer progression for prophylaxis of disease invasive forms. The methods are clinical, morphological, radioimmunological, immunoenzymatic, molecular biological, statistic. The novelty: it has been determined that at the stage of progress of dysplasia from stage І to Ca in situ the integrated form of HPV more frequently combines with an HPV episomal form, unlike micro- and invasive cervix uteri cancer, where integrated HPV forms predominate; stage ІІІ dysplasia and Ca in situ recurrence is in most cases caused be factor of 16 type HPV integration into a cell genom; high onkogenik risk episomal HPV forms raise proliferative epithelium activity of cervix uteri and affect the apoptosious indexes, high endogenik interferon level in the patients blood, epithelium activity of cervi uteri and reduce the probability of virus integration into a genome; 16 - type HPV integration in patients with Stages І-ІІІ dysplasia and Ca in situ takes place in the background of lowered interferon blood level, lowered apoptosis index level and heightened proliferative epithelium activity of cervi uteri which is one of the conditions for further disease progression. The results: it has been determined that patients with background diseases of cervix uteri, first-revealed Stages І-ІІІ dysplasia and Ca in situ need compulsory examination for high oncogenic risk HPV and, in case of revealed 16 type papillomavirus, examination for positive genome HPV integration; patients with Stages І-ІІ dysplasia without HPV integration should take the therapy of interferon drugs with further clinical follow-up of cervix uteri pathology; patients with positive HPV integration factor in Stages І-ІІ dysplasia should undergo physical (surgical) methods of treatment, diathermocoagulation of cervix uteri, cryodestruction, diathermic excision; patients with Stages ІІІ dysplasia and Ca in situ should be widely advised hysterectomy; the use of interferone drugs is advisable only to patients with episomal forms of HPV during organsaving methods of treatment, provided that patients are of high oncogenic risk; reseach of apoptosious index in the combination with mitotic index and determination of an integration factor can be used as a prognostic criteria. It has been put into practice in Kharkov Region Oncologic Clinic, Kharkov Medical Academy of Post-Graduate Education, departments of oncology, oncosurgery, oncogynecology, pediatric oncology, Kharkov Medical Radiology Reseach Institute. Branch: medicine (oncology).
